Morphological and Molecular Characterization of Focal Cortical Dysplasias
نویسندگان
چکیده
منابع مشابه
The enlarging spectrum of focal cortical dysplasias.
Focal malformations of cortical development, including focal cortical dysplasia (FCD), are among the most common causes of intractable epilepsy in children. In this issue of Brain, Jansen and colleagues provide evidence that hemimegalencephaly (HMEG) and FCD type IIa result from mosaic mutations in components of the PI3K/Akt/ mTOR (mammalian target of rapamycin) pathway, i.e. PI3KCA, AKT3, or P...
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BACKGROUND Previous reports indicate the presence of histological abnormalities in the brains of individuals with autism spectrum disorders (ASD) suggestive of a dysplastic process. In this study we identified areas of abnormal cortical thinning within the cerebral cortex of ASD individuals and examined the same for neuronal morphometric abnormalities by using computerized image analysis. RES...
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The refinements of neuroimaging have brought to the fo reground a wealth of conditions that were previously the restricted domain of clinical neuropathology. This fascinating (and often bewildering) harvest, includes primary malformations and intrauterine disruptions of the brain. To the first category belong chromosomal abnormalities and genetic or cryptogenic malformations. The latter categor...
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Focal cortical dysplasias (FCDs) are increasingly recognized as important causes of medically intractable epilepsy. To understand the potential role of the interleukin 17 (IL-17) system in the epileptogenesis of FCDs, we studied the expression patterns of the IL-17 system in 15 FCD type Ia (FCDIa), 12 FCD type IIa (FCDIIa), and 12 FCD type IIb (FCDIIb) cortical lesions and compared the results ...
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During the pre-surgical evaluation of drug-resistant epilepsy, the assessment of the extent of the epileptogenic zone and its organization is a crucial objective. Indeed, the epileptogenic zone may be organized as a simple focal lesional site or as a more complex network (often referred to as the 'epileptogenic network') extending beyond the lesion. This distinction is particularly relevant in ...
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ژورنال
عنوان ژورنال: Frontiers in Computational Neuroscience
سال: 2011
ISSN: 1662-5188
DOI: 10.3389/conf.fncom.2011.53.00178